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Typical Preparations

Infusions or teas, taken in small doses. For convenience it may be taken as a capsule or extract.

Summary
Physicians of nineteenth century America used papaya leaf to treat "fermentative indigestion," a condition of bloating, nausea, and flatulence frequently following excessive consumption of fermented foods. KingÍs Dispensatory noted that teas (decoctions) of papaya leaf helped reduce the oxalic acid content of the urine, presumably reducing the formation of oxalic acid kidney stones.
The primary use of papaya leaf in herbal medicine today is as a vermifuge, that is, to remove intestinal worms. Papaya leaf has less of the protein-dissolving papain than the fruit, so it is less likely to "dissolve" the worms, but it contains tannins that the fruit does not. These tannins protect the intestine from reinfection by "tanning" proteins in the lining of the intestinal wall so that worms cannot attach themselves.

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